Knight Campus Center for Accelerating Scientific Impact, University of Oregon, Eugene OR 97403, USA
| Received 29 Dec 2021 |
Accepted 16 Mar 2022 |
Published 16 Apr 2022 |
Recent years have witnessed a rise in methods for accurate prediction of structure and design of novel functional proteins. Design of functional protein fragments and peptides occupy a small, albeit unique, space within the general field of protein design. While the smaller size of these peptides allows for more exhaustive computational methods, flexibility in their structure and sparsity of data compared to proteins, as well as presence of noncanonical building blocks, add additional challenges to their design. This review summarizes the current advances in the design of protein fragments and peptides for binding to targets and discusses the challenges in the field, with an eye toward future directions.
